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In addition further study is
2019-05-27
In addition, further study is required to evaluate whether identified mutations influence post-translational modifications because they are important mechanism of transcription factors for regulating normal and leukemic hematopoiesis. Authors\' contributions Conflict of interest Acknowledgm
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The studies from several laboratories suggest that miR famil
2019-05-27
The studies from several laboratories suggest that miR-34 family members are the direct targets of TP53, and their upregulation can induce cancer cell apoptosis and cell-cycle arrest. It has been found that miR-34 is associated with prognosis, carcinogenesis, and survival of various cancers, includi
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br Conclusion br Conflict of interest br Introduction Classi
2019-05-27
Conclusion Conflict of interest Introduction Classically, cancer has been described as a disease involving uncontrolled cell growth. Now, however, it is apparent that cancer growth and metastasis are not solely dependent on the tumor herpes simplex virus 1 themselves, but involve pathologie
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SNDX-275 manufacturer One day post implant the chest X ray s
2019-05-27
One day post-implant, the chest X-ray showed the pacemaker lead in place within the RV (Fig. 1b, thick white arrow) with appropriate slack (thin black arrow). The pacemaker parameters were satisfactory and the patient was discharged home on the same day. Two weeks after implantation, after returnin
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br Introduction Despite the widespread use of
2019-05-24
Introduction Despite the widespread use of bone-targeted agents in the care of patients with bone metastases from prostate and breast cancer, questions regarding the optimal; choice of agent, dose, dosing frequency, and duration of therapy remain unanswered [1–6]. Our research group is interested
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However as the above results included patients
2019-05-24
However, as the above results included patients who underwent RMN ablation during its introduction to our center when physicians were still in the process of familiarization, we proceeded to compare fluoroscopy and procedural times in the most recent 50 patients undergoing ablation in each cohort. T
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It is well known that the precipitation
2019-05-24
It is well-known that the precipitation of solid cholesterol monohydrate crystals from supersaturated bile is the first irreversible physical-chemical step in gallstone formation. To study the characteristics, metastable intermediates, and kinetics in the phase transitions of bile, a series of phase
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br The slow progress in endemicity mapping of
2019-05-24
The slow progress in endemicity mapping of neglected tropical diseases (NTDs) in Africa and scaling up of mass drug administration (MDA) in all endemic countries has hampered efforts to meet the London 2020 elimination and control targets. Lymphatic filariasis is targeted to be eliminated by 2020
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br Desde su t tulo original y su
2019-05-24
Desde su título original y su actual portada, en franca coincidencia entre la lectura y el viaje, este libro nos anuncia y nos invita XL184 emprender varios recorridos insólitos. El primero signado por el pasado, cuando, en efecto, para ir a Europa desde Santiago de Chile había que pasar en barco
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br es resultado de una larga investigaci n de
2019-05-24
es resultado de una larga investigación de la obra de Juan Rulfo, pero es asimismo el fruto de largas reflexiones sobre “el arte de narrar” en general y sobre las relaciones que la literatura entabla con la cultura y la historia en que se inscribe, conexiones ellas mismas históricas. Desde el artí
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Entre las publicaciones de indagaci n epistemol gica se
2019-05-24
Entre las publicaciones de indagación epistemológica se incluyen aquellas que plantean los cuestionamientos al pensamiento científico de la época y otras que reflexionan sobre la investigación científica, sus desarrollos y consecuencias iatrogénicas. Sobre estos particulares, se destaca la necesidad
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While immunogenic action of langerhans cells had thoroughly
2019-05-24
While immunogenic action of langerhans herpes simplex virus 2 had thoroughly been illustrated, their tolerogenic action is still being in its infancy stage. Ralph. M. Steinman shared the Nobel Prize in 2011 for his work on dendritic cells and their role in immunity. He uncovered the role of dendrit
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July is a time to join
2019-05-23
July 28 is —a time to “join together to make the elimination of viral hepatitis our next greatest achievement”. Hepatitis is, belatedly, beginning to nudge its way into the global awareness. Having been neglected entirely in the Millennium Development Goals, it gets a name-check alongside AIDS, tube
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The immunohistochemistry showed infiltration of CD T cells i
2019-05-23
The immunohistochemistry showed infiltration of CD3+ T cells in dermis and few in the epidermis. The double staining of vitiligo biopsies by CD3+ and CD4+ showed that most of CD3+ cells are also CD4+. Whereas, CD3+/CD8+ are present in leading edge and lesional vitiligo skin and showing a mixture of
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In order to treat metastatic bone disease effectively
2019-05-23
In order to treat metastatic bone disease effectively all steps involved in the metastatic cascade need to be taken into account as for example the interactions between primary and secondary sites, tumour cell–bone cell cross talk and osteomimicri [8]. Therefore, concomitant targeting of both the tu
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